Nick Meadows hit a marvellous 128 as Challow & Childrey 2nd declared on 274-3 after 47 overs at Bicester & North Oxford 2nd in Division 4.
Nigel Hume (57no) and Justin Penrose (34no) were also in the runs.
Despite the efforts of Richard Coxhead (65) and Christopher Heron (47), Bicester then fell for 175 as Penrose took 5-19.
Bicester & North Oxford 2nd 10pts, Challow & Childrey 2nd 30.
Didcot's plight already looks desperate as they suffered their fifth straight defeat of the season to stay bottom.
After choosing to bat at home to Bledlow Village, they could manage only 140, Tom Kennedy top-scoring with 38 not out.
That never looked like being enough as Bledlow cruised home for the loss of four wickets in the 35th over.
Didcot 10, Bledlow Village 30.
Oxford Downs put Brackley into bat, rolled them over for just 92, and then knocked off the required runs for the loss of just two wickets.
Brackley 5, Oxford Downs 2nd 30.
Leaders Wolverton Town were 70-7 after electing to bat first at home to Buckingham Town 2nd, before Andrew Amos hit an inspired 41 not out to take them to 184.
The visitors then struggled against Stefan Pichowski (4-28) and Amos (3-39) before finally being bowled out for 168.
Wolverton Town 30, Buckingham Town 2nd 17.
Princes Risborough felt confident enough to declare one over early on 253-2 at home to Stokenchurch after Paul Strong had hit an unbeaten 105 and Adam Morton 83 not out.
But Pete Langford (46) and Arshad Latif (60) set up the run chase, which was closed out by John Zinkus (46no) as the visitors pulled off a two-wicket win.
Princes Risborough 18, Stokenchurch 30.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules hereComments are closed on this article