Depleted Letcombe were routed 11-0 away to Rayners Lane in Uhlsport Hellenic League Division 1 East.
The visitors travelled with only 11 players and had keeper Danny Joyce as an outfield player.
Hat-tricks were scored by Lawrence Yaku and Ryan Upton, with further goals coming from Dan Lake, Lee Gardner, Ben Gill, Dom Parillon and an own goal.
Headington Amateurs slumped to a third successive defeat, losing 6-3 at New College Swindon in Division 1 West.
Scorers for Headington, who trailed 2-1 at half-time were Yannick Nkwanyou, Ben Cuff and Shaun Jacobs.
Leading the way for New College, who had Ben Wells sent off 15 minutes from the end, was Gio Wrona, with a hat-trick, supported by efforts from Nathan Blackford, Josh Skeates and Lee Toomey.
Clanfield were good value for 4-0 win at home to fifth-placed Brimscombe & Thrupp, who had to play with ten men for 85 minutes.
Brimscombe’s Ian Probert was sent off in the fifth minute for pulling back Adam Little as he was going through on goal.
Little struck twice and Kieran Jennings made it 3-0 on the stroke of half-time Jennings rounded off the scoring in the 74th minute following good work by substitute Devon McCalla.
Second-placed Old Woodstock Town lost 1-0 at home to Tytherington Rocks, who stretched their lead to 14 points and should go on to win the title.
The only goal of the match was a late penalty scored by Toby Colbourne.
Carterton continued their resurgence with a 3-2 win over Hook Norton. Michael Duerden, with two goals, and Lee Watkins were on target for Carterton. Chris and Jason Tillcock replied for Hook Norton.
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