Adam Chapman and Jake Wright come into the starting line-up as Oxford United attempt to end Shrewsbury Town’s 24-game unbeaten run at home.
Chapman replaces the injured Mark Wilson for his first U’s start since the play-off final at Wembley in May 2010.
Wright missed Saturday’s 2-0 win against Swindon Town with a back injury, but the skipper returns well ahead of schedule.
Top scorer James Constable starts his three-game suspension, so Oxford boss Chris Wilder switches from 4-4-2 to 4-3-3, with Andy Whing pushed forward from centre-half into midfield.
Teenage striker Tyrone Marsh is among the substitutes and would make a first-team debut if he comes on.
Shrewsbury start the evening fourth in the npower League Two table but will return to the automatic promotion places with a victory.
Oxford (4-3-3): Clarke, Batt, Duberry, Wright, Tonkin, Chapman, Hall, Whing, Johnson, Rendell, Holmes
Substitutes: Brown, Worley, Davis, Marsh, Kerrouche
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