Joe Roff could play at fly half when Oxford University take on National 1 side Newbury at Monks Lane on Tuesday.
The former Australian international has largely been used as a centre so far, but may get the chance to shine as a playmaker.
Director of rugby Steve Hill said: "We have injuries to Jules Allfrey and Matt Sherman, who are both No 10s, so we could give Joe a run-out there."
Oxford's second team, the Greyhounds, play their first BUSA league match at Exeter Univeristy on Wednesday.
Hill said his selections will be balanced for the two games.
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