Ben Chadbone and Jordan Brown helped themselves to a hat-tricks as AFC Wallingford thra-shed Childrey United 9-1 away from home in Division 1.
Omar Mohamed notched a double and Hayden Best also scored, with Alan Haines on target for Childrey.
Harwell Village broke their duck with a 3-0 success at Crowmarsh Gifford to move off the bottom of the table.
Gareth Fenton, with a brace, and a John Rose strike made up their tally.
In Division 2, Bampton Town got off the mark with a 4-0 win over Hanney United, with goals from Dan Oyston (2), Luke Yates and Ryan Wright.
Adam Excell and Adrian Nicholls scored for Hagbourne United in a 2-1 win at Challow United in Division 4.
In Division 5, Didcot Casuals A hammered Appleton Stars 10-2, thanks to doubles from Liam Jones, Shaun Birmingham, Daryl Harper and Sean Beard.
Goals from Jon Guiry and keeper Nick Guiry, with a penalty, completed the rout with Josh King and Wayne Budizewsky replying.
Stanford in the Vale Res thrashed Hanney United Res 6-1, thanks to a hat-trick from Josh Vaughan and a Jamie Gregory double.
Wayne Gregory wrapped up their tally. Nick Clinch replied.
Dale Parker, Ian Howard and Josh Bourton all scored for Sutton Courtenay Res in their 3-1 home win over Ardington & Lockinge Res for whom Tom Bennett scored.
Meanwhile, Benson AFC Res made the semi-finals of the Nairne Paul Trophy with a 3-1 win at Steventon Res.
Dave Polley scored twice and Shane Currill once, with Kevin Allen netting for Steventon.
Division 5 side Marcham Res pulled off a shock 4-1 win against Division 2 outfit Saxton Rovers Res to reach the third round of the AG Kingham Cup.
Stuart Armstrong (2) and Shane Northcott (2) scored, with Jamie Gaffe replying.
Division 4 Harwell Village Res looked like causing an upset as they took a 3-0 half time lead over Division 3 leaders Faringdon Town Res.
A Desmond Healey brace and an Adam Spurrett strike had Harwell dreaming, but second-half strikes from James Tyler, Robbie Harrington, Paul Read and Matt Pill saw Faringdon seal a 4-3 win.
OTHER SCORERS AG Kingham Cup 3rd round: Wootton & Dry Sandford 9 (T Srawley 3, J Fisher 2, C Shahab 2, J Madge 2), Long Wittenham Athletic Res 0; Drayton Res 9 (R Chilvers 4, G Small 2, K Kogel 2, L Wheatley), Bampton Town Res 0.
Div 5: Uffington Utd Res 4 (A Williams 2, J Courtney, S Riding), Benson Lions Res 3 (I McRobbie-Smith 2, C KIrkman).
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