Wallingford welcome back flanker Will Woodward, fly half Pete Strang and centre Johnny Collett for Saturday's visit to Walcot in South West 1 East.
Last season’s top points scorer, Jackson Sayce, returns on the bench after missing the start of the season due to tendonitis.
After four straight defeats, skipper Ian Jeffreys will be looking for his side to bounce back.
Coach Chris Norrington said: “We just need to pick up a win and get the confidence back up.
“With a few of the old guard coming back to fitness, we are looking in better shape.”
Danny Godfrey and Will MacBurnie return to the Witney squad for their trip to Beaconsfield in Southern Counties North.
Jez Hicks (head injury) misses out.
Wallingford (v Walcot, away): Smith, Holton, Collett, Brettell, Simons, Strang, Viljoen, Blaszko, Hill, Keable, Rowberry, D Jenkins, Chapman, W Woodward, Jeffreys (capt). Reps: Sayce, Lewis, Dixon.
Witney (v Beaconsfield, away): from Mitchem, L Collins, Strutt, Phillips, J Lamb (capt), Monks, H Lamb, G Campbell, Griffiths, D Godfrey, S Collins, Richens, Serle, Fowler, Bennett, Muller, C Campbell, MacBurnie.
Oxford Harlequins 2nd (v High Wycombe 2nd, away, meet 12.45pm)
Oxford Harlequins 3rd (v Chesham, home, meet 1.30pm).
Oxford Harlequins 4th (v Bracknell 4th, away, meet 12.45pm).
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