Oxford Harlequins are likely to be much-changed when they travel to South West 1 leaders Redingensians tomorrow.
Lock Adam Pearson, back-row forwards Ed Davies and Ferdi Gerber, fly half Mark Forth, centre Andy Noyce and full back Huw Jones are all missing from last week's starting XV.
Duncan Lynchsmith and Neil Spottiswoode, fitness permitting, will come into the backs, while Nick Goodger and Ali McCormick boost the pack.
After two defeats with patchy displays, 80-minute focus will be the key for Quins.
Wing Nick Risk and forward Paul Lewis come into the Wallingford squad for their trip to Olney in South West 2 East.
They replace Richard Turner and Pete Thorns, who are unavailable.
Olney were promoted alongside Wallingford after just pipping them to the Southern Counties North title.
"We've got a bit of niggle with them," said Wallingford coach Chris Norrington.
"They are smarting a bit from their Reading beating last week, so it should be interesting.
"It will be a good indicator of how far we've come."
Witney are set to field an unchanged side for their Southern Counties North clash with Slough at Hailey Road.
Back Aaron Tustin returns, but has to be content with a place on the bench.
Scrum half Steve Risbridger should return from injury for Bicester's encounter at home to neighbours Buckingham.
Risbridger damaged a finger in their defeat against Aylesbury, but hopes to be fit in time.
They will be missing Nick Evans (work commitments) and Jon Rollason (unavailable).
Oxford Harlequins (v Redingensians, away, meet 12.45pm): from Chadbone (capt), Needham, DeLange, Aldous, Goodger, McCormick, Campbell, Nicholl, Young, Leslie, Sewell, Sevier, Spottiswoode, McDowell, R Jones, Gardner, Spencer, Lynchsmith, Williams.
Witney (v Slough, home): Mitchem, L Collins, J Lamb, Strutt, A Hicks, H Lamb, Gouldie, Dore, S Collins, Serle, Richens, Chatterton, M Copperwheat, Caffekey, J Hicks (capt). Reps: Tustin, J Rowland, Ashford.
Bicester (v Buckingham, home): from Morris, S Barnes, Thurlow, Malins, Cox, J Barnes, D Spencer, Nightingale, Linstrom, Risbridger, R Kenny, Lewis (capt), Nash, N Kenny, Warriner, Leverton, Morris, Rushworth, Shaw.
Oxford Harlequins 2nd (v Amersham & Chiltern 2nd, home, meet Southern Bypass, 1.30pm).
Oxford Harlequins 3rd (v Berkshire Shire Hall, away, meet Southern Bypass, 12.45pm).
Oxford Harlequins 4th (v Grove 3rd, home, meet Southern Bypass, 1.30pm).
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