Tara Kafke (Radley) blitzed her way to a championship record as she was crowned county champion in the under 20 women's 100m.
Kafke clocked 12.1 secs to take the gold medal, before adding 400m gold in a time of 58.8.
Witney's Claire Butler won the 200m in 25.8.
Elsewhere, there was a double win for another Radley's Sophie Tyers, who took the 800 and 1500m.
Oxford City's Emma Sutton set a championship record as she won the hammer with a throw of 40.62m, while other double wins came from City's Hayley Luke (100m hurdles and high jump) and Banbury's Hannah Bryan (shot and javelin).
The senior women's competition was dominated by Oxford University.
There were four non-University wins, with Rebecca Bolton (Oxford City) landing the 800m title.
White Horse Harrier Frances Briscoe took the title in the 1500m, while Amy Peacock (Banbury) won the javelin and Paula Woodland (Radley) the 400m hurdles.
Rebecca Hussey (Oxford City) took double gold in the under 17 women's 100 and 200m, while Bea Swords clocked a championship record to win the 800m.
City's Danielle Anderson won four medals, finishing first in the 300m and javelin and third in the 100 and 200m.
In the under 15 age group, Abingdon's Jemma Gregory led the way with a haul of four medals.
She won gold in the 100, 200 and 75m hurdles, and added a silver in the shot.
Emma O'Hara (Radley) also claimed three golds with successes in the discus, shot and hammer.
In the under 13 girls' age group, Banbury's Hannah Cousins pipped clubmate Jennie Weston to win both the 100 and 200m.
However, Weston won five medals in total, with victories in the shot, javelin and high jump to add to her silver medals in the sprints.
Meanwhile, Oxford City's Imogen van Zyl easily won the 800m, but had to settle for second behind clubmate Beth Hawtin in the 1500m.
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