Henley Hawks will host England Students' clash with Irish Colleges on March 14.
The students will be the third England team to appear at Dry Leas in a year after the under 19s and under 18s played a double-header last season.
Oxford University director of rugby Steve Hill is again head coach of the team, so local fans can expect to see a few Dark Blues in action.
"It's a fantastic venue and the club has a reputation as excellent hosts of major games," said team manager Keith Green Henley president Noel Armstead said: "We are delighted to host another international match at Dry Leas.
"Starting with the Under 21 World Cup in 2003, when we staged ten international matches, games at all levels have been played at Henley on an annual basis.
"Being close to a number of universities, including those in Oxford, Reading and London, we expect to attract a large crowd not to mention the support that will come for the visitors from London Irish.
"We are proud of our facilities at Henley and pleased to share them with the rugby community at large."
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