Former Abingdon Town striker Jefferson Harriott grabbed a five-goal haul in Freeland's 11-0 romp against Division 3 outfit Southrop in the second round.
The Premier Division champions put on an explosive display, with Stuart Hole, Simon Hole, Jamie Leach, Dale Kardos, Richard Trigg and Craig Simpson completing the rout.
Brize Norton dealt a crushing 7-0 defeat to Division 3 high-fliers FC Chequers.
Dan Knight led the way with a hat-trick, with Dan Frizzell (2), Chris Cope and Rob Marsh also on target.
Charlbury Town thrashed Real Islip 8-3.
Andy Woodley bagged a hat-trick. Martin Grimsley (2), Matt Smith, Bruce Claridge and Rhys Warner-Carter got the others.
Nathan Harris (2) and Jed Riddy helped Minster Lovell knock out Banbury District & Lord Jersey FA outfit Ruscote Sports 3-1.
FC Nomads beat fellow Witney & District side Eynsham A 3-1, with Tony Wilson, Tony Gerrard and Gary Lewis on the mark.
Doubles from Dan Keithley, Jon Barnes and Piotr Miekina helped Milton to a 7-2 win over Aston, Phil Benfield was also on target.
Joel King smashed a treble as Hailey hammered FC Mills 6-1. Russ Winstone (2) and Dan King also netted.
Steve Godfrey, Craig Wrighton, Jon Shuker and Carl Williams were all on target in Bampton Town's 4-1 win over Ampleforth Arms.
Richard Benham hit a hat-trick as Witney Royals progressed with a 3-0 win over Fairview.
Dan Smith (2), Chris Leach and Matty Ellis saw Hanborough to a 4-2 success at Hornton.
Pete Jenkins and Dave Large each netted a double to fire Spartan Rangers through with a 4-0 win against Duke of Wellington.
Martyn Newbold bagged a brace as North Berks League side Benson AFC beat Banbury Irish 4-3. Jo Flower and Steve Harrhy got the others.
Wallingford & Shillingford saw off Golden Ball in a 6-4 victory. Gary Rodmen and Peter Mason led the way with doubles, while Craig Whitehead and Jake Whilley also scored.
Slade Farm United won 5-1 at Cross Keys of Thame, with goals from Dave Barrie, Luke Phillips, Dean Woodham, James Allen and Callum Wynne.
Keys' reply came from a Kevin Peake own goal.
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