A crash involving a tractor and two 4x4s closed part of the A40 and caused heavy delays.
The smash happened on the eastbound side after the junction to the A415 just before 3pm.
Police, the fire service, and an air ambulance were called to the scene.
A person released from under the tractor by firefighters was taken to Oxford’s John Radcliffe Hospital in a critical condition.
Two other people were taken to the hospital with minor injuries.
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