Kidlington have been left reeling by the news that midfielder Paul Donnelly will miss the rest of the season after snapping his cruciate knee ligament.
Clanfield's Adam Lock, left, has been ruled out for the season with a cruciate knee ligament injury
Donnelly, who had only just joined the club from Oxford City, was making his full debut in last Saturday's 2-1 Oxfordshire Senior Cup defeat at Bicester Town when he fell awkwardly in a tackle.
Manager Karl Grossmann said: "It was an innocuous situation, a 50-50 challenge in the middle of the park, and all of a sudden, he was on the ground in agony.
"It's a massive blow to him personally, and to us. On Boxing Day morning, we will have a charity game to raise some money for him."
Meanwhile, Kidlington will also be without Danny Morris, Geoff Talboys, Leighton James and Frazer Gills for their home Division 1 West clash with Shrivenham, but Owen Bunce and Danny Mason return to the squad.
Clanfield's Adam Lock has also damaged cruciate ligaments which will keep him out for the rest of the season.
Joining him on the sidelines for the rest of the campaign is Paul Franklin with a knee injury.
Richard Mace is unavailable for their tricky trip to Winterbourne, but Mark Bowles and Peter Osborne return.
Chipping Norton Town will be without Craig Dore (holiday) as they visit Harrow Hill.
Striker Mark Odom faces a late check on his troublesome knee, and Paul O'Hare is rated very doubtful with a hamstring strain.
Prolific striker Carl Henry makes his long-awaited debut for in-form Witney United as they look to extend their run at Headington Amateurs.
But Paul Lennon (hamstring) remains sidelined, while Ricky Dash is rested.
Nick Acock and Michael Beale return for Middle Barton at home to bottom side Ross Town after missing last week's 4-1 Senior Cup defeat at Henley Town.
But Adrian Field (ankle) is ruled out, along with Eddie Hanks and Danny Phillips.
In the Premier Division, brothers Marc and Jamie Jackson and Stuart Huxley are doubtful for leaders North Leigh as they take on fellow title-hopefuls Southall at Eynsham Park.
Carterton Town have snapped up midfielder Mark Jordan from Pewsey Vale, and he goes into the squad for the clash with Wootton Bassett at Kilkenny Lane.
Mark Threlfall (groin) is ruled out, but Paul Sherwood may return from injury.
Didcot Town include three new signings for their trip to Pegasus Juniors.
Andy Parsons joins from Abingdon United, while Lee Newport from Wantage and keeper Keith McLoughlin, from Leighton Town, have also signed.
Richard Peirson is a doubt for Abingdon United's home game with Gloucester United after suffering concussion in Tuesday's 2-2 draw against Hook Norton.
Andy Baird returns for Brackley Town's trip to Bishops Cleeve. Paul Anderson is still missing, while Adam Dedman is suspended.
In Division 1 East, Quarry Nomads' promising youngster Tristan Lawrence is set to join Abingdon United following a seven-day approach.
Meanwhile, Quarry bid to keep their unbeaten away record intact at bottom side Drayton Wanderers.
David Beatham is back in Letcombe's squad after recovering from injury for their home game with Chalfont Wasps.
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