Ross Doyle was hit by a stolen red Vauxhall Astra -- registration number F581 HUR -- which had been taken from Kennington two weeks earlier.
He was killed in Pegasus Road at 8.45pm on December 13, 2000, as he returned from football practice with his friends.
The car was abandoned at the scene.
The owner did not report the car stolen until after Ross's death, but Det Insp Dermot Norridge emphasises he is not under any suspicion.
Following the car's theft, it was driven by several people in Blackbird Leys.
"One person used it more than anybody else as his own car," Det Insp Norridge said.
That person was arrested but released without charge.
In the past two years, officers have arrested five people in their late teens and early 20s.
Some have been arrested more than once. All have been released without charge.
The most recent arrests in May this year were a 21-year-old woman, 21-year-old man and another man, 19.
A £10,000 reward for anyone who gives information leading to the arrest and conviction of the car driver still stands.
Call Oxford police on 01865 266333, or Crimestoppers on 0800 555111.
The police officer leading the investigation into Ross Doyle's death says he does not know the identity of Ross's killer.
Det Insp Dermot Norridge wants to banish the perception on the Blackbird Leys estate that police know who was driving, but can not make evidence stick.
"It is a fact I don't know who the driver was and who was in the vehicle," he said.
"There may be a perception that we do know who it was but because of a lack of evidence we can not put them in court. That is not the case.
"We still need the help of the public to come forward and identify the driver so we can place that person before the court."
He appealed to anyone with information about the incident to break the code of silence surrounding Ross's death.
There is still an amnesty for passengers in the car. They will be given immunity from prosecution if they identify the driver.
Det Insp Norridge appealed to the consciences of those in the car.
"They are two years on in their lives and Ross is not," he said.
"I ask them to consider how they would feel as a parent to have their children struck down in such circumstances?"
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