West Oxfordshire District Council has endorsed a plan to improve air quality in Chipping Norton.
Councillors now want approval to de-trunk parts of the A44 so heavy goods vehicles are routed away from the town.
The area around Horsefair in the town was declared an Air Quality Management Area in 2005 because of the high levels of nitrogen dioxide pollution caused by traffic and, in particular, HGVs.
Proposals include changing road signs and imposing vehicle weight limit restrictions on traffic coming into the town.
A consultation process has now started.
District councillor David Harvey, cabinet member for environment, said: "People living in Chipping Norton have had to put up with the effects of heavy traffic for many years."
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