The Liberal Democrats have won in Bicester and Woodstock making Calum Miller the first ever MP for the new constituency.
Calum Miller won the seat with 19,419 votes and Conservatives' Rupert Harrison came second with 14,461 seats.
Bicester was previously part of the Banbury constituency.
The turnout for Bicester and Woodstock was 67.82 per cent.
The Lib Dems also won in Witney, Oxford West and Abingdon, Henley and Thame, and Didcot and Wantage - causing a Conservative wipe-out across the county.
READ MORE: General Election: Liberal Democrats win Henley and Thame
In his winning speech, Mr Miller said: "This is a historic moment for Oxfordshire, and this is an historic night for the Liberal Democrats."
"Thank you to Ed Davey, for reminding us that you can be serious about the things that matter, without taking yourself too seriously."
"Thank you most of all to the people of Bicester and Woodstock, this new constituency - thank you for your trust in me.
"If you're struggling to make ends meet, or to put a roof over your head, or you're relying on food banks to feed your family, I will fight your corner.
"If you run a small business facing rising costs, or your customers have less to spend, I will champion your interests.
"And if you're one of the countless people I've met waiting weeks for a GP appointment or an NHS dentist, or if you've been denied a hospital appointment you urgently need, I will do everything in my power to restore our NHS."
READ MORE: Liberal Democrats win three seats at leisure centre count
He added: "If you feel let down by this Conservative government, now you have a chance for positive change.
"No matter how you voted in this election, I make this promise - I will represent each and every one of you to the best of my abilities, and I promise to be your local champion in parliament."
Thank you to the people of #BicesterandWoodstock
— Calum Miller 🔶 (@CalumMillerLD) July 5, 2024
I am honoured to be elected as your MP.
This is my home. I stood because I want to serve my community, to speak for my neighbours and to represent this wonderful part of Oxfordshire.
I won’t let you down. pic.twitter.com/WLOSrPXHpb
Here is a breakdown of the full results for Bicester and Woodstock.
Calum Miller (Liberal Democrats) – 19,419
Rupert Harrison (Conservatives) – 14,461
Veronica Oakeshott (Labour) – 8,236
Augustine Obodo (Reform UK) – 5,408
Ian Middleton (Green) – 2,404
Tim Funnell (Social Democratic Party) – 291
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