Didcot face the ignominy of going down two years in a row after being relegated at Division 5 champions-elect Great Brickhill.
The home side declared after 47 overs after amassing 281-5 courtesy of Shannon Tubb (76), John Cook (46) and Greg MacDonald (40).
Matt Jones (86) fought hard to stave off the inevitable, but Tubb took 4-17 and Didcot were all out for 162.
Great Brickhill 25pts, Didcot 5
Brackley are also in danger of consecutive relegations, but kept in touch with the teams above them thanks to some extraordinary resistance at home to Bicester & North Oxford 2nd.
Last pair Ollie Goddard and Josh Markham held out for 19 overs to secure a draw and with it three extra points that could prove vital.
Earlier Graham White had hit 58 in Bicester's 186-7. Andrew Wingfield Digby had taken 5-54.
Brackley 8, Bicester & North Oxford 2nd 15
Aston Rowant 2nd seem sure to finish runners-up, but kept alive their slim chance of pipping Great Brickhill for the title by beating Leighton Buzzard Town 2nd.
Tim Foster took 5-59 in an outstanding 26-over spell as Town reached 177-9.
Mark Walker (85) and Dave Ridgley (44) set up Rowant's five-wicket win.
Aston Rowant 2nd 25, Leighton Buzzard Town 2nd 8
Great & Little Tew 2nd's batsmen were uncharacteristically out of sorts at Oxford & Bletchingdon Nondescripts, with only Sam Catling (44no) excelling.
Garry Adamson took 4-22 and Toukeer Ahmed 4-25 as Tew were all out for 121, then Edward Pettit Mills (55no) took Nondies to 123-2.
Oxford & Bletchingdon Nondescripts 2nd 25, Great & Little Tew 2nd 3
Ali Jarvis (60) and Jonathan Cooke (50) saw Banbury 3rd on their way to 241-6dec at home to Abingdon Vale 2nd, for whom seamer Robin Newman toiled away to finish with figures of 3-118.
Michael Howe-Davies was the main contributor to Vale's 213-8.
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