TWO people have been hospitalised after a crash on the M40 not far from the Oxfordshire border.

The incident took place at about 12.50am this morning (February 18) between a white Ford transit van, a silver Mercedes E220 and a grey Audi A3.

It took place on the M40 between junction 5 and 4 on the southbound carriageway, near Stokenchurch and High Wycombe.

READ MORE: A34 disruption after 'serious crash' and flooding

A man and a woman, both in their 40s, were taken to hospital with serious injuries, where they both remain.

Detective Sergeant Darren Brown, of the Joint Operations Roads Policing Unit said he is now appealing for any witnesses to the crash to come forward and speak to police about it.

Anyone with information or dashcam footage of the incident is urged to contact police reference number 43240077486.