The HSBC branch is Bicester is set to close its doors for good today (June 20).
The bank is located at 1 Sheep Street in the town centre.
This comes amid the closure of hundreds of UK bank branches with Barclays and Halifax also shutting sites this year.
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The move will leave thousands of customers without access to an in-person branch.
Bosses have cited the increase in people banking online rather than in person as a reason for the closures, with 266 planned for closure across the UK.
But the Bicester branch is the only site due to shut in Oxfordshire in this latest round of closures.
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