Police are appealing for witnesses following a collision on the B4009 Wallingford Road, just outside South Stoke.
A red BMW 328i was travelling from Goring towards South Stoke when it lost control and landed on its roof at around 11.12pm on Thursday.
There were five people in the car and three people suffered serious injuries and were taken to the Royal Berkshire Hospital, in Reading.
Sgt Bill Sykes said: "There may have people that could have witnessed the incident, or seen the car before the collision and I urge anyone with any information to contact me."
Anyone with information is urged to contact Sgt Bill Sykes via 08458 505 505, or if you do not want to talk to the police or give your name, call the Crimestoppers charity on 0800 555 111.
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