Abingdon business park, former site of the MG car factory, is up for sale at £48m. The MG factory closed in 1979 and the site was sold to insurance company Standard Life.
It is now home to 40 businesses, including Swets library journals business, EBI Foods, which produces food coatings and batter mixes, and software company Schlumberger.
Richard Venables, of VSL and Partners of Kidlington, which handles lettings, said interest was likely to come from institutional investors - another insurance company or pension fund.
Current income from the park totals £3.28m a year.
The park includes former Oxford Instruments offices, which have been empty since the company restructuring more than six years ago.
The 40,000 sq ft building was sold last year to a joint venture between IVG and Axa, and is now available for rent.
Mr Venables said: "It has been completely refurbished and is also being marketed as a environmentally friendly low-energy building." Commercial property in Oxfordshire was holding up well during the credit crisis, he said "Our view at the current time is that despite the crisis in the financial markets this has not yet hit home in the commercial property market.
"The commercial investment market has seen a fairly big correction but rental levels in Oxfordshire are holding up and there are no shortage of new inquiries for property takers."
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