Oxfordshire Fire and Rescue Service have confirmed four casualties are in hospital as a result of two accidents on the M40 in the early hours.
A car, van and HGV were involved in a crash on the M40 northbound between Junction 10 and 11 near Banbury at around 4am.
One person suffered potentially serious injuries and two others sustained minor injuries.
Road closures were put in place when a secondary collision occurred on the southbound carriageway.
On the opposite carriageway, two lorries jackknifed, with one HGV driver sustaining abdominal injuries.
All four people were taken to the John Radcliffe hospital for treatment.
Police, fire and rescue and four ambulances attended the scene after a number of 999 calls were received at around 3.40am.
National Highways later tweeted warnings to drivers of a "large fuel spillage" and a "substantial amount of debris" on the road.
A diversion route was put in place while accident investigation work took place.
The road remained closed until around 2pm for emergency resurfacing due to the significant fuel spill.
A SCAS spokesperson said: "We received a number of 999 calls around 03:40 this morning all reporting a serious accident on the M40 northbound between junctions 10 and 11 involving a car, van and HGV.
"At/near the same location, two lorries on the opposite carriageway had jackknifed.
"On the northbound carriageway, our teams treated three patients; one with potentially serious injuries and the other two with minor injuries. All three were taken to the John Radcliffe Hospital in Oxford for further treatment.
"On the southbound carriageway, one of the HGV drivers had sustained abdominal injuries and was also taken to the John Radcliffe Hospital.
"In total, we had four ambulances, a paramedic team leader in a rapid response vehicle and an emergency doctor at the two incidents."
A message from our Editor
Thank you for reading this story and supporting the Oxford Mail.
If you like what we do please consider getting a subscription for the Oxford Mail and in return we’ll give you unrestricted access with less adverts across our website from the latest news, investigations, features, and sport.
Follow us on Facebook, Twitter, Instagram and Tik Tok for more.
You can also join the conversation in our Facebook groups: stay ahead of traffic alerts here, keep up to date with the latest from court here, share your favourite memories of Oxford here, get your daily dose of celebrity news here and take some time out with news that will make you smile.
If you’ve got a story for our reporters, send us your news here. You can also list an event for free here.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here