Women who put on 10 pounds then lose it within a year as they struggle to diet are at greater risk of heart disease, a new study warned.
And the more a woman has yo-yo dieting, the more the risks increases.
The findings highlights the importance of maintaining a healthy weight for a healthy heart as yo-yo dieting may make it harder for women to control a variety of heart disease risk factors.
These are body mass index, cholesterol, blood pressure, blood sugar, smoking, physical activity and diet.
Senior author Assistant Professor of medical science Dr Brooke Aggarwal at Columbia University Vagelos College of Physicians and Surgeons in New York said: "Achieving a healthy weight is generally recommended as heart healthy but maintaining weight loss is difficult and fluctuations in weight may make it harder to achieve ideal cardiovascular health."
The study involved 485 overweight women with an average age of 37 who had an average body mass index 26.
They were taking part in American Heart Association's Go Red for Women Strategically Focused Research Network basded at Columbia.
They were questioned on how many times other than during pregnancies they had lost at least 10 pounds, only to regain the weight within a year.
They were assessed on American Heart Association's - Life's Simple 7, a measure of how well people control the seven important heart disease risk factors.
Nearly three quarters of the women (73 per cent) reported at least one episode of yo-yo weight loss, with a range of zero to 20 episodes.
It was found women with one or more episodes of yo-yo weight loss were 82 per cent less likely to have an optimal body mass index of between 18.5 and 25 - classified as neither underweight or overweight for their height.
They were 51 per cent less likely to be rated as moderate, and 65 per cent less likely to be rated as optimal overall on Life's Simple 7.
Importantly they study found thee more episodes of yo-yo dieting, the poorer they scored on Life's Simple 7.
The detrimental impact of weight-cycling on the overall Life's Simple 7 score was most striking in women who had never been pregnant.
Prof Aggarwal added: "The women without a pregnancy history were likely younger and might be those who started weight-cycling at an earlier age.
"We need to identify critical periods for the effect of weight fluctuation on heart disease risk over the life course to find out whether it is worse when women start on a dieting roller-coaster at an early age."
She explained the results may not apply to men and it relied on a woman's recollection of her fluctuating weight.
The findings could not clarify whether yo-yo dieting had an adverse effects on Life's Simple 7 factors or rather that those who don't adhere to guidance on Life's Simple 7 have a harder time maintaining low weight and end up yo-yo dieting more frequently.
Commenting on the findings cardiologist Suzanne Steinbaum, director of Women's Heart Health at the Heart and Vascular Institute at Lenox Hill Hospital in New York said: "Anytime we do studies that are survey-based, which means it really comes down to people's memories, it's not as accurate as other types of studies.
"But here's the truth.
"When we look at the population studied, it is really people age 37 on average who are yo-yo dieting, gaining weight, losing weight, within a 10 pound differential.
"And we've seen this before, that when this happens, people do worse in terms of their risk factors, their blood pressure, their cholesterol, their body mass index, their sugars, really how they eat, their dietary choices.
"These all really suffer. When there's yo-yo dieting we can really surmise that the lifestyle choices are fluctuating."
Prof Aggarwal said: "We hope to extend the study five to ten years to confirm these results and look at long-term effects.
"However, there has been prior research that showed similar results in men, with those who weight-cycled having twice the risk of cardiovascular death in middle age."
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here