The timetable for trains which will operate from the new Oxford Parkway station near Kidlington from October has been released.
On October 26, the first train will depart from the station and arrive at London Marylebone just 56 minutes later.
The line is the first new rail link between London and a major British city for over 100 years and is part of a £130m investment from Chiltern Railways.
It is expected that 1,000 more passengers will use the Oxford line every morning.
The new service will see two new fast trains per hour throughout the day between Oxford Parkway and Bicester Village station and the capital.
Three trains will run from Oxford to London between 6am and 7am every morning, with a key commuter train departing at 7.24am.
Graham Cross, director at Chiltern Railways, said: "The new line is an incredibly exciting and important milestone.
"As of October, passengers will have fast and direct services to the capital."
There will also be a 'silver' train service on the 7.24am train, which will be fitted with an espresso bar and a business zone.
The majority of the trains during the day will be geared to business with free Wi-Fi, power sockets and spacious seating for working.
During the off-peak period, the majority of London to Oxford Parkway services will depart at regular half-hourly intervals.
Following a public consultation, the train operator is offering a service from Islip to Oxford Parkway so that passengers can connect with the faster services to the capital.
The weekend timetable has been developed to mirror the weekday off-peak service.
The full timetable is available on the Chiltern Railways website chilternrailways.co.uk
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