A car has hit a tree leaving the A4074 Henley Road partially blocked.
The road is partially blocked in both directions from the junction of New Road and Wallingford Road and A415 Berinsfield.
Emergency services, including an air ambulance, are currently on the scene dealing with the incident, which involved one vehicle.
Police were called to the incident at 4.10pm.
South Coast Ambulance Service said it was currently assessing four people at the scene, one of which is a female in her 60s being assessed for possible back injuries.
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