Bicester produced a superb display to power past Beaconsfield 38-17 in the EDF Energy Senior Vase.
Flanker Anthony Nightingale and Fijian winger Esawa Rakacikaci both bagged try doubles.
Bicester's other tries came from hooker Steve Barnes and full back Tom Edgar The only downside for Bicester saw fly half Adam Spencer go off with a broken rib.
Three tries in each half gave Witney a 36-0 success at home to Cooper Avon Tyres.
Witney's tries came from Will Worrall (2), Henry Lamb, No 8 Owen Fowler, Tom Harper and Dan Purkiss.
Wallingford's unbeaten start came to an end when they lost 37-26 at Trowbridge.
The visitors never recovered from going 20-0 down after 17 minutes They did score tries through Elliott Simmons, Derek Viljoen, Henry Venners and Kris Blaszko, but the damage had been done.
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