A male pedestrian from Banbury has died after reportedly being hit by a van near the village of Steeple Aston near Bicester.
The A4260 Oxford Road southbound was closed due to a three-vehicle accident at about 8am between North Aston Road, Duns Tew, and the B4030 in Steeple Aston.
Thames Valley Police spokeswoman Charlotte Redman said: "Sadly I can confirm that a man in his late 50s from Banbury died of his injuries following the collision this morning.
"We will be issuing a witness appeal in due course but until this happens any witnesses should call police on 101."
South Central Ambulance Service spokesman David Gallagher said: "We were called at 8.01am following reports that a male pedestrian had been hit by a van.
"We sent two ambulances, a doctor and an air ambulance and the man was taken to the John Radcliffe Hospital with life-threatening injuries."
The crash happened on the Oxford-bound side of the road on the dual carriageway section.
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